But how does zebrafish research factor into working on humans and seeing how we react to various compounds and medicines? For that, Jack explained that zebrafish were something called a “model organism.” Having not only an organism that your work can easily be transferred from, but also having something catalogued by a lot of researchers, it has made their research go so much smoother.
“When we work with these organisms, we work with them first and foremost because there's a translatable nature to it, but also the fact that because there are so many studies that involve them, they're well catalogued. So, if you're filling in different pieces of the puzzle with zebrafish, then if someone else comes back with a certain effect a drug has, we can so "Oh, well this paper had this effect, so this is more than likely the reason for the response."”
This all sounds like a lot of complicated and hard work. And you would be right to think that, as Jack says that that hardest part of these research projects are the parts where it isn’t even in their hands. They work with other departments as well, most notably the chemistry department, and they must make sure the compounds work for their needs.
“The biggest hurdle we have had is that this project has been going on for a while, so there has been a lot of handoffs … So, the biggest challenge we've had is basically making sure the compounds are consistent, and it's been a bit of a process to learn because we've learned there's a particular range, so if the ring isn't completely cyclized, the reaction doesn't happen.”
Jack is almost at the end of his graduate journey, as he’ll be graduating this coming December. He has a good idea of where exactly he wants to end up in his future endeavors, but he knows that his options aren’t limited.